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Unformatted text preview: a. passive diffusion • mostly zero order but can be first order too • no energy • no resistance • fit most drug • need concentration gradient (high to low) b. facilitate diffusion • first order • no energy • faster than passive • need carrier mediated transport • can be coupled with active diffusion-example : Na+/K+ pump - use the energy of gradient of one ion to pump the other one c. active diffusion • requires energy • need carrier mediated transport • go against concentration 4. Draw a typical injection curve and label each portion The steepness of the curve represent the redistribution period when the drugs are being redistribution to different compartment inside the body -- first though the tissues with highest blood flow which would receive most of the drug then to other tissue with less blood flow. • this curve is related to the volume distribution 5. 6. Draw percent ionization graph of a weak acid...
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