Note 05 - a. passive diffusion • mostly zero order but...

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Pharmacology Discussion Answers to Handout #1 1. 4 key principles of pharmacology a. pharmacodynamics - the study of the effects of the drugs on the body b. pharmacokinetics - the study of the body’s reaction to the drugs (absorption, metabolism, and elimination) c. pharmacogenetics - the study of the relationship between a specific person’s genetics makeup and his or her response to drug treatment d. toxicology - the study of adverse action of the drug on the body’s functions 2. first pass metabolism - the reduction in the bioavailability of the drug at the target site when the drug passes through one membrane a. in other words, the reduction in the concentration of the drug at the target site How to calculate the bioavailability? RN-XRNx 100%=% of bioavailability - RN - the amount of drug - X - the molarity of the drug that undergo metabolism Every drug administration methods is subjected to first pass metabolism except for intravenous (IV) 3. 3 different types of transport processes
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Unformatted text preview: a. passive diffusion • mostly zero order but can be first order too • no energy • no resistance • fit most drug • need concentration gradient (high to low) b. facilitate diffusion • first order • no energy • faster than passive • need carrier mediated transport • can be coupled with active diffusion-example : Na+/K+ pump - use the energy of gradient of one ion to pump the other one c. active diffusion • requires energy • need carrier mediated transport • go against concentration 4. Draw a typical injection curve and label each portion The steepness of the curve represent the redistribution period when the drugs are being redistribution to different compartment inside the body -- first though the tissues with highest blood flow which would receive most of the drug then to other tissue with less blood flow. • this curve is related to the volume distribution 5. 6. Draw percent ionization graph of a weak acid...
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This note was uploaded on 05/03/2010 for the course CHEM CHEM 118 taught by Professor Staff during the Spring '10 term at UCSD.

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Note 05 - a. passive diffusion • mostly zero order but...

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