Equation Sheet 1

Equation Sheet 1 - Steady State Plateau Percent of the...

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e, they are able to move through the membrane (aka more absorption) actor controlling the approach to plateau. Acid - = - A HA 10pH pka Base + = - BH B 10pkb pH Bioavailability (%, F) %, F= = * * AUCoralAUCIV AUCoral DoseIVAUCIV Doseoral Volume of Distribution (V d ) = = ( - ) Vd AC amount in body dose mg plasma concentration ( ) mgL Elimination Rate Constant (k) k = 1/hr Rate of Elimination (RE) = * = * * = * RE k A k Vd C CL C Total Clearance (CL) = * = * = CLLhr Vd k k AC0 AAUC Renal Clearance (CL R ) = * ; = CLR fe CL fe amount secreted unchangeddose Concentration Time Equation = - * C C0e k t Half-Life Elimination / = . t1 2 0 693k Fraction Remaining in the Body = ; = CC0 12n n number of half life Calculating C0 and k = - // = - * . logC0 y intercept k slope 2 303
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Unformatted text preview: Steady State Plateau Percent of the Plateau Level % = -1 12n Steady State Dose ( Ass ) = ; = Ass Rok R0 infusion rate Steady State Concentration ( Css ) = Css RoCL Loading Dose (LD) = * = * LD Vd Css Vd target concentrationbioavailability Affinity (K d ) = [ ][ ]= K2K1 D R DR Kd Total Receptors (R TOT ) R TOT = [D R] + R FREE Fraction of Receptor Occupied (FO) % FO = [ ] + D D Kd Total Drug (D TOT ) D TOT = [D R] + [D] Total Receptors (R TOT ) R TOT = [D R] + [R] Inhibitor Constant / = +[ ] KD' KD1 I KI // = +[ ] KI IC501 X KD Dose Rate (dr) = = +[ ] dr EC50'EC50 1 I KI Dissociation Constant of Inhibitor (K I )...
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This note was uploaded on 05/03/2010 for the course CHEM CHEM 118 taught by Professor Staff during the Spring '10 term at UCSD.

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Equation Sheet 1 - Steady State Plateau Percent of the...

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