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Unformatted text preview: Steady State Plateau Percent of the Plateau Level % = -1 12n Steady State Dose ( Ass ) = ; = Ass Rok R0 infusion rate Steady State Concentration ( Css ) = Css RoCL Loading Dose (LD) = * = * LD Vd Css Vd target concentrationbioavailability Affinity (K d ) = [ ][ ]= K2K1 D R DR Kd Total Receptors (R TOT ) R TOT = [D R] + R FREE Fraction of Receptor Occupied (FO) % FO = [ ] + D D Kd Total Drug (D TOT ) D TOT = [D R] + [D] Total Receptors (R TOT ) R TOT = [D R] + [R] Inhibitor Constant / = +[ ] KD' KD1 I KI // = +[ ] KI IC501 X KD Dose Rate (dr) = = +[ ] dr EC50'EC50 1 I KI Dissociation Constant of Inhibitor (K I )...
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