Autonomic_Figs_BW22

Autonomic_Figs_BW22 - epinephrine * * monoamine oxidase...

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General Properties of ANS Provides critical homeostatic mechanisms Reflexes mediated by local circuits in spinal cord and brainstem An effector and sensory * system 2 (or 3) Divisions: Sympathetic Parasympathetic (Enteric) * somatosensory & visceral afferents Sympathetic Parasympathetic Rest and digest Fight or flight
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Responses to / Recovery from Emergencies Fight or flight* response (sympathetic) 2200 Respiratory rate 2200 Heart rate Vasodilation in limb muscles Vasoconstriction in viscera Dilation of lung airways 2200 2200 General alertness Rest and digest response (parasympathetic) 2200 Respiration to resting level 2200 Heart rate to resting level Vasoconstriction in limb muscles Vasodilation in viscera Constriction of lung airways Secretion returns to normal Alertness returns to normal *also “fright”
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CNS Centers Regulating the ANS Figs. 11-2, 11-3
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Pre- and Postganglionic Neurons
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Postganglionic Sympathetic Synapses tyrosine DOPA dopamine norepinephrine
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Unformatted text preview: epinephrine * * monoamine oxidase COMT * *catecholamine-O-methyltransferase Catecholamines Autonomic Pathways Sympathetic = Thoracolumbar Parasympathetic = Craniosacral 1 1 cervical ganglia 2 2 prevertebral ganglia 3 3 adrenal medulla Adrenal Medulla Autonomic Pathways Sympathetic = Thoracolumbar Parasympathetic = Craniosacral 1 cervical ganglia 2 prevertebral ganglia 3 adrenal medulla Transmitters & Receptors (Traditional View) Postganglionic Preganglionic ACh ACh nAChRs (fast EPSP) Norepi Parasymp. Symp. ACh Target Cells Muscarinic AChRs 1, 2, 1, 2, 3 ARs Postganglionic Preganglionic ACh + Peptides ACh nAChRs (fast EPSP) mAChRs (slow EPSP or IPSP) Norepi Parasymp. Symp. or ACh ACh + Peptides Target Cells Muscarinic AChRs 1, 2, 1, 2, 3 ARs + ATP P1, P2 Rs nAChRs + peptides various Rs +/- VIP VIP-R Transmitters & Receptors (Current View)...
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Autonomic_Figs_BW22 - epinephrine * * monoamine oxidase...

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