Glucocorticoid_Figs_BW

Glucocorticoid_Figs_BW - Anatomy of the Adrenal Gland 0...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
Anatomy of the Adrenal Gland 0 Adrenal Cortex : Zona glomerulosa (Aldosterone) Zona fasciculata (Glucocorticoids) Zona reticularis (Androgens) Medulla (catecholamines)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Steroid Hormone Synthesis Corticosteroid binding globulin (CBG) or Transcortin
Background image of page 2
Control of Cortisol Secretion Stimulation Inhibition ACTH CRH Cortisol ADH Adrenal Cortex Anterior Pituitary Hypothal- amus Diurnal rhythm Feeding Anxiety Neuro- transmitters Stress Lymphokines CRH = corticotropin releasing hormone ADH = antidiuretic hormone ACTH = adrenocorticotropic hormone 16 24 08 10 100 1000 Cortisol (nM) Time of Day
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Normal Atrophy due to long- term corticosteroid therapy Hypertrophy due pituitary adenoma secreting ACTH (Cushing’s disease) 2 cm Pathology of Adrenal Cortex
Background image of page 4
Effects of Cortisol 1. Stimulates gluconeogenesis (from AAs) in liver 2. Stimulates glycogen synthesis in liver 3. Stimulates protein catabolism, especially in muscle 4. Inhibits protein synthesis in most cells 5. But, increases protein synthesis in liver
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/03/2010 for the course BISC 307L taught by Professor Herrera during the Spring '08 term at USC.

Page1 / 8

Glucocorticoid_Figs_BW - Anatomy of the Adrenal Gland 0...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online