Pancreas_Figs_BW 2

Pancreas_Figs_BW 2 - ATP X K + ↑ Ca 2+ Exocytosis Insulin...

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Immediately Available Fuel Molecules Glucose Fatty Acids Amino Acids Storage Macromolecules Glycogen (liver, skeletal muscles) Triglycerides (adipose tissue) Protein (muscle) ANABOLISM CATABOLISM Metabolism the sum of all the chemical reactions in the body. Absorptive (Fed) State Postabsorptive (Fasted) State Nutrients absorbed from gut No nutrient absorption Potential excess of fuel Potential deficit of fuel Anabolic reactions Catabolic reactions
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Flow of Molecules through Metabolism
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glucagon Pancreatic Islets Pancreas Duodenum Insulin (absorptive): glucose uptake, glycogenesis, lipogenesis Glucagon (postabsorptive): glycogenolysis, lipolysis, gluconeogenesis α β ( δ – somatostatin)
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Control of Insulin Secretion in Pancreatic β -Cells GLUT-2 transporter ATP-sensitive K + channel Voltage-gated Ca 2+ channel Glucose Amino Acids Energy metabolism
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Unformatted text preview: ATP X K + ↑ Ca 2+ Exocytosis Insulin Release stimulated by : GI hormones (espec. GLP-1) Parasympathetic activity Release inhibited by : Sympathetic activity β-Cell Insulin Stimulates Glucose Uptake Actions of Insulin A. Carbohydrates 1. Stimulates glucose transporter 2. Stimulates glucokinase 3. Stimulates glycogen synthase B. Lipids 1. Inhibits lipolysis in adipose tissue 2. Stimulates formation of FFAs and lipogenesis C. Protein 1. Stimulates Na +-dependent amino acid uptake 2. Stimulates protein and RNA synthesis, inhibits breakdown D. Ions 1. Stimulates the uptake of K, PO 4 , and Mg E. In pancreas 1. Inhibits secretion of glucagon Actions of Glucagon ↑ cAMP Inhibition of glycolysis Fatty acids Acetyl CoA (2-C) Citric acid cycle ATP production keto acids excess Diabetes Mellitus Type 1...
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This note was uploaded on 05/03/2010 for the course BISC 307L taught by Professor Herrera during the Spring '08 term at USC.

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Pancreas_Figs_BW 2 - ATP X K + ↑ Ca 2+ Exocytosis Insulin...

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