Mech_Acquired_Imm_Figs_BW

Mech_Acquired_Imm_Figs_BW - (Globulins are A, 1, 2, , )...

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Immunoglobulins IgD IgM Plasma cells first secrete IgM J Chain Disulfide bonds Later, recombination of different C region genes causes class switching On naïve B-cells, functions as a BCR IgG IgE IgA J Chain Secretory component or or (Globulins are A, α 1, α 2, β , γ ) Transmembrane region C C V V C C V V heavy chain light chain hinge region Fab Fc
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Transcytosis of IgA From Janeway, et al., Immunobiology , Garland Science http://www.ncbi.nlm.nih.gov/books/bv.fcgi?indexed=google&rid=imm.figgrp.121700
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Rearrangement of Immunoglobulin Genes 0 From Janeway, et al., Immunobiology , Garland Science
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Diversity of Immunoglobulin Genes 0 (DNA) ···CCCTGG··· ···CCCCGG··· ···CCCCCG··· (RNA) ···GGGACC··· ···GGGGCC··· ···GGGGGC··· gly-thr gly-ala gly-gly V region + J region ···CCCCCC TGG··· Light Chain (LC) 40V x 5J x 1J = 200 different VJ combinations Heavy Chain (HC) 200V x 12D x 4J x 1C = 9600 different VDJ combinations Randomly combining … 200 Light Chains
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Mech_Acquired_Imm_Figs_BW - (Globulins are A, 1, 2, , )...

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