PHYSIO_FINAL_EXAM

PHYSIO_FINAL_EXAM - PHYSIO FINAL EXAM Go over 2 slides on...

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PHYSIO FINAL EXAM Go over 2 slides on innate and acquired immunity from Exam 3!! LECTURE 26: LAST! *RECALL FROM BIO220 Major functions of the Immune System: Defend against infection by viruses, bacteria, fungi, parasites, etc. Destroy and recycle worn-out cells Ex: erythrocytes, neutrophils o 200 billion and 100 billion RBCs/neutrophils are destroyed per day Identify and destroy abnormal (cancer) cells Diseases and Clinical Conditions: Allergies Autoimmune disease  o Ex: Type 1 diabetes mellitus; systemic lupus erythematosus  Immunodeficiency diseases o Primary (inherited) o Secondary (acquired) Limits tissue/organ transplants Types of Immunity Innate  (non-specific, inherited, rapid, no memory) Acquired  (specific, adaptive (needs to be activated by a threat), slower,  memory) *ANATOMY OF LYMPHATIC SYSTEM Lymphatic organs:  Thymus:  where majority of T lymphocytes migrate to after made in bone  marrow Spleen:  where fixed and mobile cells react to blood that travels through;  purifies blood of worn out RBCs and neutrophils, and also  bacteria/viruses/debris etc.  Outer capsule   red pulp   white pulp   venous sinuses So efficient that only 1 or 2 passes through the spleen  completely sterilize the blood  Also acts as a blood reservoir because the tissue has smooth  muscles (1 pint stored)
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Hemorrhage signals to spleen to contract and release its  blood o Ex: blood donation source; takes 6 weeks until  regain normal RBC counts again  o Splenic artery:  delivers blood to small venous sinuses  Like in placenta, blood is not contained in vessels Surrounded by  red pulp  (macrophages) and  white pulp  (lymphocytes)  Walls have fixed phagocytes  Mobile:  macrophages and neutrophils Fixed:  Kupffer cells (in liver)  GALT (gut-associated lymphoid tissue):  unencapsulated that deals with  long digestive tract so makes up 70% of lymphoid tissue Lymph nodes:  Encapsulated lymphatic organ  o Afferent/Efferent lymph vessels and capsule o Unencapsulated:  diffuse lymph nodes Ex: adenoids in upper pharnyx Ex: tonsils  Ex: GALT (70% of lymphoid tissues) Red bone marrow:  come from hematopoietic stem cells but still present in  long bones in adults; make B and T lymphocytes o B lymphocytes:  live in bone marrow  Lymph vessels:  cluster in armpit, neck, and groin (where can be felt) o Well positioned to detect pathogens  Lymphatic fluid percolates   encounters lymphocytes to be collected in  efferent lymph vessel  Muscular pumping in lymphatic veins back to blood   veins collect and drain  into lymphatic duct 
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This note was uploaded on 05/03/2010 for the course BISC 307L taught by Professor Herrera during the Spring '08 term at USC.

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PHYSIO_FINAL_EXAM - PHYSIO FINAL EXAM Go over 2 slides on...

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