330JP14 - BISC 330L Dr John Petruska 330JP14 Lect 13...

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BISC 330L Dr. John Petruska 330JP14.ppt Lect. 13 Appendix: Protein Targeting to Membranes and Lecture 14 References: (3rd Ed 2005), Chap. 21, 31.3 (6th Ed 2007), Chap. 19, 30.6
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Stryer Fig. 30.31 The SRP targeting cycle on RER membrane.
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Recent view of SRP interaction with signal peptide emerging from ribosome channel. (K. Nagai et al, MRC Laboratory for Molecular Biology. Cambridge, England) Alu domain M domain Note: are the α and β subunits of SRP receptor (SR) SR SR
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SRP54 SRP19 (MRC Laboratory for Molecular Biology, Cambridge, England) 7SL RNA (Alu domain ) (M domain, 296-504, which binds 7SL RNA )
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N-TERMINAL SIGNAL PEPTIDE SEQUENCES OF EUKARYOTIC PROTEINS TARGETED TO ROUGH ENDOPLASMIC RETICULUM: EXAMPLES OF SIGNAL SEQUENCES THAT BIND TO SRP54. Signal peptidase cleavage site / Human proinsulin + MALWM R LLPLLALLALW GPDPAAA FV Human interferon γ + M K YTS YILAF Q LCIYL GSLG CY Human α -fibrinogen + MFSM R IVCLVL S VV GTAWT AD Human IgG heavy chain + MEFGLS WLFLVAIL K GVQC EV Human influenza virus A + M K L K LLVLLYAFVA G DQ Hum. gr. hormone + MATGS R TS LLLAFGLLCLPWL QEGSA FP Bovine growth hormone
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This note was uploaded on 05/03/2010 for the course BISC 330L taught by Professor Petruska,tower during the Spring '07 term at USC.

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330JP14 - BISC 330L Dr John Petruska 330JP14 Lect 13...

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