330JP23 - BISC 330L Dr. John Petruska 330JP23.ppt Lect. 22...

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BISC 330L Dr. John Petruska 330JP23.ppt Lect. 22 and Lecture 23 Citric Acid Cycle: Energetics References: (3rd Ed 2005), Chap. 19, (17) (6th Ed 2007), Chap. 17
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Stryer Fig. 17.20 Biosynthetic roles of citric acid cycle. Overview showing (in red) the the links called anaplerotic reactions. Note: the green arrow is the pyruvate carboxylase reaction, using CO 2 & ATP to convert pyruvate to oxaloacetate, especially important in
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Stryer Fig. 17.19 Overview of citric acid cycle regulation. i nhibitory ; ADP, pyruvate, NAD + & CoA are stimulatory . (also NAD + and CoA ) Pyruvate dehydrogenase Isocitrate dehydrogenase α -Ketoglutarate dehydrogenase
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Fig. 19.26 Regulation of the Citric Acid (TCA) Cycle. Note: pyruvate dehydrogenase is not only feedback inhibited by its products, acetyl-CoA & NADH, but in mammals it is also inhibited by phosphoryl- ation when these products reach high levels in matrix of mitochondrion (Fig. 19.27).
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Fig. 19.27 Regulation
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This note was uploaded on 05/03/2010 for the course BISC 330L taught by Professor Petruska,tower during the Spring '07 term at USC.

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330JP23 - BISC 330L Dr. John Petruska 330JP23.ppt Lect. 22...

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