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330JP23 - BISC 330L Dr John Petruska 330JP23 Lect 22 Review...

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BISC 330L Dr. John Petruska 330JP23.ppt Lect. 22 Review: TCA Cycle Links & Regulation and Lecture 23 Citric Acid Cycle: Energetics References: Garrett & Grisham, Biochemistry (3rd Ed 2005), Chap. 19, (17) Berg, Tymocko & Stryer, Biochemistry (6th Ed 2007), Chap. 17
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Stryer Fig. 17.20 Biosynthetic roles of citric acid cycle. Overview showing (in red) the the links called anaplerotic reactions. Note: the green arrow is the pyruvate carboxylase reaction, using CO 2 & ATP to convert pyruvate to oxaloacetate, especially important in human and other mammals.
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Stryer Fig. 17.19 Overview of citric acid cycle regulation. Note: ATP, NADH, acetyl-CoA & succinyl-CoA are i nhibitory ; ADP, pyruvate, NAD + & CoA are stimulatory . (also NAD + and CoA ) Pyruvate dehydrogenase Isocitrate dehydrogenase α -Ketoglutarate dehydrogenase
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Fig. 19.26 Regulation of the Citric Acid (TCA) Cycle. Note: pyruvate dehydrogenase is not only feedback inhibited by its products, acetyl-CoA & NADH, but in mammals it is also inhibited by phosphoryl- ation when these products reach high levels in matrix of mitochondrion (Fig. 19.27).
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Fig. 19.27 Regulation
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