BISC330-MT1-Spring08

BISC330-MT1-Spring08 - Page 1 Name _K.2 g Data pmvided for...

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Unformatted text preview: Page 1 Name _K.2 g Data pmvided for bio-atoms: Atom: H C N 0 P S Atomic weight 1 l2 14 16 3] 32 Elcclroncgulivity 2.1 2.5 3.0 3.5 1| 2.5 | l (":7 pninls) liach blank space corrcctly answered is worth 2 points. Consider 1h: following types of covalent bonds in biological molecules: C-(TE C-ll, C-N. C 0. (1-3. H-N. H-O. H-S, O-P. 0-S,S-S (a) Of all the bonds shown above. the two least polar are C, C and 5 —5__. each with about 0 % ionic character. (0—H) (9-05 rjb)'l'he two most polar are [5-0 and Q-E , each having ~ lI’D % ionic character. (c) Oxidation of biological molecules in the body yields the following main waste product molecules. D . w thfg‘trr‘rchnc of each. [ 0+4) (i) Ll, Q , containing 2 _B_o 0_ bonds only. Struclurcfl pl): H H \o/ «hid (030) Sal Fab) (_ 5—H) (ii) V H19 .containing’.’ 35$ bonds only. Structure (1 pt): H H\/ (cor-bail drbl. I?!) (iii) 7 ‘ C02 , containing 4 C “'0 bonds only. Strucqu (l pt) : ' ‘ O=C=O (61%;);0 7 (NM) (id—O (iv) um; .conlaining4 3-51 ,2 CIN ,and2__g-o bonds. Structure (2 pts): Pnch Mme Kej M Msw 2. (34 prints) Each blank space cormme answered is wunh ‘2 poims. d...— 6" ‘ 5 a4“ - u ¢W . Céhflr moi-<2 6*“ 6‘50"” (a) The Simpitbl n'nim) acid is M31559} ([6 . whow molecuh' has i CC and ‘ (7-1] bonds. Upon midaliun in the body. it rcicagcs energy in the amount of / 7O kan-‘mole or a n 3 _ MAL-Em. approximately. / c“ "5., “(0M 21 Sh ' \ rk: u“ “)2, (C-Horo—o -> c—o + oar: «Mora60’t‘2m4/"we‘"3 ,5“ - —: {0 MM C—c +049 -7 2 C—0 5 9.660% 5'0 = ('70 M/Moag sigma» -AH" , 1.. (-70 Qc‘e/ m cage 9/ 2 Mw 3 75' er {CI3+1C:'L)+1<'N)+Z.C/63 ‘- '-' 6—4-24 +/c/4az 75f 1'37 75' I70 1%, L53 5'8 (b) By comparison. the simplest hydrocarbon. named m (flame . which hue U C-H bonds. releases g 40 kcal-‘mole or =l5‘ kcab'gm. In ocean sediments. this hydnmurhon is l pmduwd by ancient anauob'fc m _mina. e, and accumulates in deep ocean bnuums i" the rum “r [‘4 ice that micascs ._m<—.*‘.ir‘4~ng_ gas bubbles upon healing. _ Slum work: (liqu Z{(C-H +o—o-a C—o+o—H -AH°z40Ec‘2/u,@) -A H‘ = W50) =2¢0 Qcafl/AHLQ~ fé‘é": [{w/jm‘ (—i u, é-u “w : Iz+q=/63/n.a€e i M (H cf.) CC 5). (c) One amino acid. named Mgcnf‘q‘ . has 2 C-S bonds; another, named M, has I (f-S and l S-H. Which of these is not essential in human diet'.’ (1):] s i‘ 6! n L . ()I'Um 20 amino acids uxd to make proteins l O we not made by human calls and therefore arc £2 5 an H in hmnan diet. [4) Jim Page 3 Name _. __ 3. (.18 points) Please use the following pKa valucs fur amino acids: Sidechain of a-COOH u-NH-g Asp (ilu Cys 'I'yr His Lrs Arg 2.1 9.6 3.9 4.3 8.3 10.9 6.0 10.8 12.5 (i) Calculmc the pl vulu: For web ot‘tlxe following dipcptidcs: (3 pts each) Ser‘l'hr 5tfi(é) AspLys 6.4 $2) Hislxu 1.2 (g) GlyGlu 3 .‘L (3) AsuCys 5‘2. (5‘) (ilnArg ".0; (I!) Show \wrk: gum éC 2.: HM) : $25- 4135!“ Wu +u.3) e 9.2. 1' (2.! 43919.4 J-(aj’): M9135 q E" Asncgz, 15(1.H~23)=é(/o.q>=s.z WSLw ’;(6.m?.c)= 50943.75; 6!” Avg %.(q.6f-(z§) ’ éé12-13" ".05 a! IL] (ii) Consider the following polypquidcs. with ID amino acid residues each: 4- f 40.! A. ilu-Leu-Gln-Lys—Ala-llis.Lcu-A¥g-Ala u—a — - .- {- B.@Val-Asp-Asp—Scr-Glu—Val-Glu-I.ys-(ily .- I f - I" C. Gly- ixy@cst-Sel (ily-Ala-Gly-Val D. Sly-PIO-A‘Eg-Gly-PIU-GllI-Gly-PNhAIu-(ily _ 4- . F.. (Hy-l.cu-(ilyolX‘s-(i1y-(iln-(ilyuXrg-Gly@ Indicate which of the peptides :\-E has the property described bclow (2 pts each) (a) Net charge - am pll 7. b (b) Net charge = +2 at pH 7. ,_V_E¥__ (c) Lowest pl valuz. B (d) Highest pl value. ,E,_____ (c) Contains no sulfur. (f) May form S-S crossfink. C: Lg) Must likely no form (x helix. A (h) Most likely to form [3 sheet. C; (i) Releases least kcal-‘mole upon oxidation. C (j) Releases most kcall'molc upon oxidation. A 34': '9‘" LI: Fl: " "a"- Pa-gt: 4 n NIL: (.55! (4.": '- 37}. (30 swims] lva. the general structure and brietkr describe the function nfhiolngiu? nulvmcrs whosu I - ' . * :——.—- ' . . -——-— . . - . ' monomexs an Imked by the lollowmg covalent bonds and Indicate where m ' '- w v rum Kuch bonds an: hydrolyzed when food :5: digested in Suzunan body. 3 cg. .. . . _ (a) Phosplzcdicstcr bonds (15 pts) znc‘e o L [€0th some Nuciel‘c ACJaS (DNA “4‘31 QMAl“ :2! 1,,_’.._$,_2’- pgggm‘eshr bald- -———~ P— —~ ___————— N. _‘ o . "' B =A,C,6;. U “ ‘9’ 97f 0' 7" IA ‘ ‘ If ’ “0.1 fl rtfiv 9'” e: A,c ,Cor'r . " z E l ' 2 S a'spNA Chat}, 014 _ k Is “sadly 4‘0qu M ;;W A dgpkenfi Nabomcn'ch ’\ As used +0 J" a ' ’ '4' V 1’ G ‘ W A v \N prfiflfifa’figdfl’ 6w“ (9 1— W on“ A b 0W4ng mflN 3 $s'DNA aged 40 5+0“ c .' W {A onglufi- GM‘SJL‘QS’ ‘ ) "‘ w _ &.ZWAV$WMLE%M (W (b)Pcptidcbonds(15p /" ~ 4.6352 IuQflCQ of 0041;100ch EM meruc‘ by @2 9' "A ‘1 H 0 W Planaf‘p 1 I IN,“ "L I" kac. N'hxrmu' 4‘ . “Nun-«J I! :1” c Md“ lfl’fflw CM’J (to) O +2616” {?non POIM¥(H,A,fé‘/‘§:Lm;’ E w( h 1* s. ,N, 7—19 94"“ (lug/301m 41:6“?! V'E’C’Y —' —- . —.3_b£2 Ev" K K5323: 461 A #6 EM Mamwflamw, /\ 01,3414 (DUO: {fa-Skfl‘é (‘firpromok6 of“ Z d Pm ‘2”; 145m AMDQQK I ‘ ) x~_'-__’_f/ " OHM” VIST(p" (3121mm, ral'auus leaéafn - {2x Awful-o. of Isfiudunw ray/1M0 gum l7 a; gfigmmemm ’51 1351.133 ‘ c'w-MW‘) "51% .448- - .mn’é’tém nu... Page 5 Nnmc ; (36 points) (a) Define what is meant by primary. Necmulxuy, tertiary and qualervmrjv «mature in pmlcins. (I 6 pls) P‘LMOU‘j s‘h'. — 5%“;La:|n;:%\ n aw" 00”“ by “Nah”! C)“ Pay) MS vCa’ ca! 55 a 9+. # Q aufioldw‘ SM“- _ "‘ . 3mm My lffdbmdms be’vwcen Pa *‘SCWPS‘Q-fi-“h‘l'x : l ,5912 {Y 41‘ . . , n ad £ sec.an6.a4y s ac, rs TQ-(hax‘d 6h ‘ a \ nhraci-lou’ [ Marcy“; when“? elecmwt 2mm“? “fig: b3 5. «a Qua-A'irf‘afj S’ff - Mud-#15 LIA/Jami Cowpfe'zA [rt-Ferach L 2A$M5W+tr+mg é4—vu u ‘ b) Draw the gench xuuclurc of D— and T.- amino acids and briefly explain why I.-nminn arid residucs (end In fonn n right-hang; alpha helix in proleing whems D-amino acid residues tend to form a lefi-handed helix. (12 pts) '1). dmmDO—C‘d ; x 1"“: / o . ‘ K 23p pal..ka «j H“”"$r‘rw‘3v‘ (c) Briefly describe the conditions needed to form a pgallel beta sheet in a protein, and give at least 4 examples of beta promoters. (8 pts) / page»; (ova Maw 356;, y, ,Mcggm a”; J" W . AVISTCP> P 7%7‘ ‘9 Pfl'sh" “"57"”; . - Mum @¢)?_:>/40(/s; 5M ...
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BISC330-MT1-Spring08 - Page 1 Name _K.2 g Data pmvided for...

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