3-11-09_Notes - Two pairs of chromosomes, one from mom, one...

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Two pairs of chromosomes, one from mom, one from dad Made in a small location, one after the other Cross-section seen by staining of heavy ion At rare times, we can section to see both nuclei  Typical section showing  Idealized image from a whole series of electronic graphs Know table 2.1, all the organelles, structures and functions Especially for ER, GA, mitochondria The nucleus is the genetic headquarters, containing DNA inherited from both parents The nuclear envelope has two membranes connected by nuclear pores The pores are protein complexes that keep DNA inside nucleus but allow selected RNA  and proteins to move through pore Nuclear pore complex is a complicated protein It looks like a spool, where the inner hole is where RNA and proteins can enter the cell  through cytoplasm Has 8-fold symmetry Proteins and complexes can look similar if folded from 8 different sides Long, thin filaments come out from cytoplasm side and nuclear side Outer membrane and inner membrane are fused together There is a hole which connects the cytoplasm to the nuclear membrane If the pores weren’t there, the RNA and proteins could leak out It would be a transient hole, be there one instant and then close up This is a bad situation Filter built into the structure Made up of dense, protein structures, and loose, fibrous structures Fibrous structures are gelatinous, anchored to something that looks like a disk with a  hole in it Called a nuclear cage, things that leave nucleus have to leave through this cage before  they can leave, it is like a door The looser collection of fibers on the other side prevent other parts from getting not the  nucleus at all   fibril Designed to filter out things that are not supposed to go in or out of the nucleus  Protein transport going in and out, RNA going out, DNA staying in
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This note was uploaded on 05/03/2010 for the course BISC 330L taught by Professor Petruska,tower during the Spring '07 term at USC.

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3-11-09_Notes - Two pairs of chromosomes, one from mom, one...

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