07-Mutation3 - Exposure to ionizing radiation Mutation 1...

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Unformatted text preview: Exposure to ionizing radiation Mutation 1 Laurel Birch Bio 151 Investigations in Genetics and Evolution Prof. Kellar Autumn autumn@lclark.edu 2/22/10 Bio 151 - Prof. Autumn 1 2/22/10 Bio 151 - Prof. Autumn "Only 0.1 R" Don't worry? 2 Mutations? Ellis van Creveld syndrome Recessive mutation in Amish community Traced to single original immigrant Environmental or heritable? http://en.wikipedia.org/wiki/Ellis-van_Creveld_syndrome 2/22/10 Bio 151 - Prof. Autumn Volpe, E.P. and P.A. Rosenbaum. 2000. Understanding evolution, 6th ed. McGraw-Hill, New York. ISBN 0697051374. 3 2/22/10 Bio 151 - Prof. Autumn Volpe, E.P. and P.A. Rosenbaum. 2000. Understanding evolution, 6th ed. McGraw-Hill, New York. ISBN 0697051374. 4 X lethal mutations reduce male sex ratio 20 eggs Spontaneous abortion 16.8 fertilized 13.8 implanted 8.4 develop to week 4 7 develop to week 8 6.2 babies born (31%) 2/22/10 Bio 151 - Prof. Autumn Volpe, E.P. and P.A. Rosenbaum. 2000. Understanding evolution, 6th ed. McGraw-Hill, New York. ISBN 0697051374. 5 2/22/10 Bio 151 - Prof. Autumn 6 Volpe, E.P. and P.A. Rosenbaum. 2000. Understanding evolution, 6th ed. McGraw-Hill, New York. ISBN 0697051374. The Genetic Code 1 DNA Base change causes sickle-cell anemia Glutamic acid 2nd position substitution of A with U Valine 2/22/10 Bio 151 - Prof. Autumn Volpe, E.P. and P.A. Rosenbaum. 2000. Understanding evolution, 6th ed. McGraw-Hill, New York. ISBN 0697051374. 7 2/22/10 Bio 151 - Prof. Autumn Volpe, E.P. and P.A. Rosenbaum. 2000. Understanding evolution, 6th ed. McGraw-Hill, New York. ISBN 0697051374. 8 One Sickle-cell copy may lead to heart abnormalities NCAA May Force Schools To Test For Sickle Cell Trait In the past decade, more than a dozen young athletes who died during vigorous workouts were found to have the sickle cell trait. Some health experts are concerned the required screening could lead to black students with the trait being singled out and excluded from sports. http://public.npr.org/anon.npr-mp3/npr/me/2009/12/20091228_me_05.mp3?sc=16&orgId=1&forsearch=0&topicId=1066 http://www.npr.org/ 2/22/10 Bio 151 - Prof. Autumn 9 ...
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This note was uploaded on 05/03/2010 for the course BIO 151 taught by Professor Autumn during the Spring '10 term at Lewis and Clark Community College.

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