10-MutationII - Normal Base Pairing Pyrimidine Mutation II...

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Unformatted text preview: Normal Base Pairing Pyrimidine Mutation II Bio 151 Investigations in Genetics and Evolution Prof. Kellar Autumn [email protected] 2/23/10 Bio 151 - Prof. Autumn 1 2/23/10 Purine Purine Pyrimidine Bio 151 - Prof. Autumn 2 C-G Transitions T-A C-G Transition Mutations T-A Spontaneous mutagenesis: G to A Purine to Purine Spontaneous mutagenesis: A to G Spontaneous mutagenesis: C to T Spontaneous mutagenesis: T to C C-A T-G T-G Pyrimidine to Pyrimidine C-A 2/23/10 Bio 151 - Prof. Autumn 3 2/23/10 Bio 151 - Prof. Autumn 4 Transversion mutations Silent Substitutions 3rd position transition GGC EMS CCG ethyl-G replicates to any base! CCG = Pro Transversion = -Purine changes to Pyrimidine -Pyrimidine changes to Purine Bio 151 - Prof. Autumn 5 2/23/10 2/23/10 Bio 151 - Prof. Autumn Same! 6 Missense Sickle-cell Anemia 2/23/10 Bio 151 - Prof. Autumn 7 2/23/10 Bio 151 - Prof. Autumn 8 Nonsense Frameshift 2/23/10 Bio 151 - Prof. Autumn 9 2/23/10 Bio 151 - Prof. Autumn 10 Mutations in the Developmental Process 2/23/10 Bio 151 - Prof. Autumn 11 ...
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This note was uploaded on 05/03/2010 for the course BIO 151 taught by Professor Autumn during the Spring '10 term at Lewis and Clark Community College.

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10-MutationII - Normal Base Pairing Pyrimidine Mutation II...

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