03 Class Biological and Personality Models of Depression-Bipolar_class

03 Class Biological and Personality Models of Depression-Bipolar_class

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5/27/2009 1 PSY 423: MOOD DISORDERS Biological and Personality Models of Depression/Bipolar SUMMER 2009 CHRYSTAL VERGARA AND PAULA YANES Thought Question WHY IMPORTANT TO WHY IMPORTANT TO UNDERSTANDTHE THE BIOLOGY AND GENTICS OF DEPRESSION / BIPOLAR? Biological Aspects of Depression Clues that there may be a biological aspect Symptoms Familial Transmission Anti-depressant Medications Depression as a side effect
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5/27/2009 2 Biological Aspects of Bipolar Disorder Clues that there may be a biological aspect Familial Transmission (higher than MDD Familial Transmission (higher than MDD) Efficacy of medications Relative inefficacy of psychotherapy & other treatments Genetic Research: Terms Proband Individual in a family who has a particular disorder Phenocopy A problem that has the same symptomatology as a particular disorder, but is in fact caused by something else Genetics: Family Studies Methodology Identify a proband and interview all primary relatives (mom, dad, sibs, children) to determine their psychiatric status Identify non-disordered control families and do the same thing for comparison Use base rate stats from epidemiologic studies
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5/27/2009 3 Family Study Results Collaborative Depression Study (Winokur et al., 1995) Looked at Probands and families with severe MDD First degree relatives: 10.4% Control relatives: 4.9% Family Study Results Bipolar Disorder Results Parents of Proband: 23.4% Siblings of Proband: 22.7% Second degree relatives: 1-4% General Population: about 1% Family Study Results Early Onset Dysthymia (by age 21) Klein et al., 1995 Dysthymic, MDD and control probands Dysthymia seems to run in dysthymic families (not MDD families as much) MDD and personality disorders also elevated among Dysthymic proband families
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5/27/2009 4 Family Study Results Children of Depressed Parents 50-80% have a diagnosable mental disorder during childhood or adolescence About 50% of children with a depressed parent develops a depressive disorder Inherit both genes *AND* environment from parents!!
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03 Class Biological and Personality Models of Depression-Bipolar_class

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