HW3 - Homework 3: Due at the beginning of class 03/12/10...

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Homework 3: Due at the beginning of class 03/12/10 Problems 1. Proteins have to fold into a single configuration to be able to function as molecular machineries. Now consider the following 2D model of protein folding. The model assumes (1) The protein has 21 amino acid residues. (2) The protein is confined in a plane and the amino acid residues can only occupy the positions in the lattice as shown below. (3) Each residue can only proceed to the nearest lattice site. (4) There is a steric hindrance prohibiting the residues separated by 2 residue distance to overlap at the same spot. (5) Any residue pairs separated more than 4 residue distances can be positioned at the same spot. (6) The position of the first residue is fixed. In the random coil configuration, the protein can take any possible “random walk” configurations (only one of many configurations is shown in the left figure below). In the folded configuration, this protein folds into a single unique configuration as shown in the right figure below. Calculate
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This note was uploaded on 05/04/2010 for the course CH 43445 taught by Professor Lim during the Spring '10 term at University of Texas.

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HW3 - Homework 3: Due at the beginning of class 03/12/10...

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