ch17 - C C S-CoA O CoASH acetyl-CoA thiolase Citric acid...

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1 Fatty Acid Catabolism Chapter 17 17-1 Mobilization and transfer of FA from adipose tissue 17-3 TG DG MG FFA + glycerol FFA FFA Adipose TG lipase (ATGL) 17-4 What 2 chemical transformations must occur to go from glycerol to glyceraldehyde- 3-P? Oxidation of Fatty Acids Outline of oxidation process: 1. Activation by formation of CoA derivative 2. Transport into mito via carnitine carrier system 3. Oxidation by series of rxns in which fatty acyl chain shortened by 2C at a time = β -oxidation. Occurs exclusively in mito.
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2 17-5 1. Activation 17-6 2. Transport into mitochondria Inhibited by Malonyl-CoA H 3 C N + CH 3 CH 3 CH 2 CH CH 2 COO - OH carnitine 17-8 3. Oxidation reactions How is the enzyme reoxidized? CoQ CoQH 2 ETF = electron-transferring flavoprotein ETF 17-8 17-15 VLCAD 17-7
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3 Palmitoyl-CoA + 7CoA + 7FAD + 7 NAD + + 7H 2 O 8 acetyl-CoA + 7FADH 2 + 7 NADH + 7H + -2 (activation) 106 (net) 17-11 Oxidation of odd-chain FA H 3C H 2 C C H 2 H 2
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Unformatted text preview: C C S-CoA O CoASH acetyl-CoA thiolase Citric acid cycle Citric acid cycle How is the succinyl-CoA then utilized to make energy? Regulation of fatty acid oxidation 17-12-OOC CH 2 C S-CoA O malonyl-CoA ACC = acetyl-CoA carboxylase Ketone bodies 17-18 Succinyl-CoA Succinate CoA transferase (missing in liver) (Insulin elevated in well-fed animals) gluconeogenesis FBPase-1 (by PFK-2) 23-26 Carbo feeding: G/I ratio decreases: •No release of glucose or ketones •FA synthesis stimulated ∀β-ox inhibited • • • 4 (stimulated by starvation; inhibited by carbo feeding) Metabolic effects generally opposite those of insulin 23-30 Starvation or fasting state: G/I ratio increases: •Glucose and ketone bodies released •FA synthesis inhibited • • • • • •...
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ch17 - C C S-CoA O CoASH acetyl-CoA thiolase Citric acid...

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