ch16 - core structure (3 million) •30 E 1 tetramers...

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1 Citric Acid Cycle Chapter 16 Fermentation is a low-energy process - no net oxidation: Complete oxidation of glucose to CO 2 = 2880 kJ/mol Complete ox of ethanol to CO 2 = 1326 kJ/mol lactate x 2 = 2652 kJ/mol original glucose 2652/2880 = 92% of original free energy present per mol glucose is still present in fermentation product (lactate) Respiration = process by which aerobes obtain energy from oxidation of fuel molecules by molecular oxygen. 16-1 30-32 ATP/glucose 19-1 16-7 16-2
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2 16-6 Pyruvate dehydrogenase complex (PDH) 14-13 Pyruvate decarboxylase rxn 16-6 Pyruvate dehydrogenase complex (PDH) 16-4 disulfide (dithiol) 16-6 Pyruvate dehydrogenase complex (PDH) 16-3
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3 16-6 Pyruvate dehydrogenase complex (PDH) 13-27 •Tightly (often covalently) bound to enzyme •Can handle 1- or 2-electron transfers 13-24 Pyridine ring •Dissociate from enzymes •2-electron transfers only 16-6 Pyruvate dehydrogenase complex (PDH) Eukaryotic complex : •60 E 2 monomers (52000) in a
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Unformatted text preview: core structure (3 million) •30 E 1 tetramers (154000) attached to core •12 E 3 dimers (110000) •1-3 copies of a kinase (62000) + 1-3 copies of a phosphatase (100000) •6 copies of protein X Total complex = 9 X 10 6 16-5b pyruvate CoA-SH NAD + Acetyl-CoA CO 2 NADH + H + PDH PDC (E 1 ) PDC (E 1 ) P ADP ATP kinase phosphatase (-) (-) (-) (inactive) (active) (+) Ca 2+ (+) 4 15-20 16-7 K eq = 3.3 X 10 5 p. 622 16-7 p. 625 16-7 5 p. 611 16-12 (mixed anhydride) ADP ATP Nucleoside diphosphate kinase Substrate-level phosphorylation High P transfer potential 16-7 Co-Q Co-QH 2 E-E-p. 628 16-7 ∆ G o ’ = +29.7 kJ/mol (Co-QH 2 ) 16-13 (2 carbons) 6 16-18 16-15 Anaplerotic Reactions = “filling up” pyruvate + CO 2 + ATP + H 2 O OAA + ADP + P i 16-16 16-15 pyruvate + CO 2 + NADPH + H + L-malate + NADP + 16-15 PEP + CO 2 + GDP OAA + GTP...
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This note was uploaded on 05/04/2010 for the course CH 53890 taught by Professor Raymonds during the Spring '09 term at University of Texas.

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ch16 - core structure (3 million) •30 E 1 tetramers...

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