ch14,15.Pt2 - Energetics of gluconeogenesis Balance sheet:...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Phosphohexose isomerase Bypass 2 Bypass 3 14-16 G o ’= -16.3 kJ/mol G o ’= -13.8 kJ/mol What are the ATP coupling coefficients for these two substrate cycles? -1 -1 0 0 2 pyruvate + 4ATP + 2GTP + 2NADH + 2H + + 4H 2 O glucose + 4ADP + 2GDP + 2NAD + + 6P i Balance sheet: Energetics of gluconeogenesis K eq ~ 850 highly favorable goes to completion G ~ -16 kJ/mol (compare with ~ +63 kJ/mol for reversal of glycolysis from 2 pyruvate) Coordinate regulation of glycolysis and gluconeogenesis 15-11 Bypass 2 15-15 Control at bypass 2 What is the metabolic logic of these regulators? [ ATP ] [ ADP ] + [ AMP ] = energy charge 15-14 15-16
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 15-16 - O P O O - O 15-17 β β (bifunctional) 15-17 Regulation of bifunctional PFK-2/FBPase-2 by phosphorylation How does phosphorylation alter activity of bifunctional enzyme? Coordinate regulation of glycolysis and gluconeogenesis 15-11 Acetyl-CoA Regulation of pyruvate kinase 15-19 What is the logic of these acting as inhibitors?
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 4

ch14,15.Pt2 - Energetics of gluconeogenesis Balance sheet:...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online