ch14,15.Pt1 - Overview of Energy Metabolism Glycolysis,...

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1 Glycolysis, Gluconeogenesis, PPP, Glycogen Metabolism Chapters 14, 15 Overview of Energy Metabolism 16-1 14-3 Fermentation and Respiration glucose Fermentation products (anaerobic) O 2 CO 2 + H 2 O (aerobic) Fermentation Respiration Stanier 6-6 homolactic alcoholic Glucose Fermentation 14-2 1. add phosphoryl groups to glucose (low phosphate transfer potential bonds) = priming 2. chemically convert low energy phosphorylated intermediates into compounds with high phosphate group-transfer potential (by oxidation) 3. chemically couple the energy-yielding hydrolysis of these to ATP synthesis Chemical strategy: glucokinase (liver) Reaction 1
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2 15-12 Hexokinase isozymes Reaction 2 Reaction 3 What kind of chemistry does PFK catalyze? Nucleophilic substitution: attack of C1- OH on ATP Committed step for glycolysis!! Reaction 4 Schiff base formation (conversion of ketone to imine) (Protonated Schiff base) McMurry and Begley “The Organic Chemistry of Biological Pathways”, p. 21) 14-5 Reaction 4: aldolase (Carbinolamine) (iminium ion)
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This note was uploaded on 05/04/2010 for the course CH 53890 taught by Professor Raymonds during the Spring '09 term at University of Texas.

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ch14,15.Pt1 - Overview of Energy Metabolism Glycolysis,...

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