CH13pt2 - ionizes Why is ATP such an energetic molecule Why...

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4 Most regulatory enzymes of energy metabolism are allosterically modulated by adenine nucleotides (ATP, ADP, AMP). ATP + AMP 2 ADP adenylate kinase [ ATP ] [ ADP ] + [ AMP ] = energy charge High-energy phosphate bonds : phosphoric anhydride 13-12 G 0 ’= -30.5 kJ/mol + P i High-energy phosphate bonds : acyl phosphate (mixed anhydride) 13-14 High-energy phosphate bonds : enol phosphate 13-13 High-energy phosphate bonds : phosphoguanidines 13-15
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5 13-19 13-11 Electrostatic repulsion destabilizes ATP relative to ADP + P i Resonance stabilization of free phosphate ion Hydration of free phosphate ion ADP immediately
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Unformatted text preview: ionizes Why is ATP such an energetic molecule? Why is equilibrium so far to right? V&V14-6 phosphoanhydride bonds are kinetically stable: Role of AMP and pyrophosphate: in some rxns, 2 terminal phosphate groups enzymatically removed as pyrophosphate (PP i ), leaving AMP: ATP coupling coefficient? PP i + H 2 O 2P i ∆ G°' = -19.2 kJ/mol ATP + H 2 O AMP + PP i ∆ G°' = -45.6 kJ/mol Δ G = Δ G o + RT ln [Products] [Reactants] Standard free energy change vs. reversibility in cell: Q = mass-action ratio A B...
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CH13pt2 - ionizes Why is ATP such an energetic molecule Why...

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