CH11.Pt1 - to lipid tail Transport across membranes 11-25 4...

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1 Membranes and Transport Chapter 11 What does it take for a cell to be “alive”? • Integrity of compartment • Energy • Respond to environment • Reproduce itself 11-3 Lipid Bilayer 11-4 2 x 15 = 30 Å ~20-30 Å Total thickness ~50-60 Å (5-6 nm) Bilayer is a two-dimensional fluid 11-16 11-16 11-16
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2 11-15 Low temp High temp 11-19 Bilayer is asymmetrical: lipid asymmetry 11-5 11-3 Bilayer is asymmetrical: protein asymmetry Membrane proteins Basic structure of membranes determined by lipids, but specific function of membranes determined by protein components. Proteins are held in place by hydrophobic interactions with lipids Anchored 11-6
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3 11-8 Integral membrane proteins glycophorin 11-7 Bacteriorhodopsin 11-9 11-11 Hydropathy plots 11-14 GPI = glycosylated phosphatidylinositol Anchored proteins = Covalent attachment
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Unformatted text preview: to lipid tail Transport across membranes 11-25 4 11-26a G = G 2 G 1 = RT ln [ C 2 ] [ C 1 ] Simple diffusion of uncharged solute- driven by chemical gradient 11-26b Simple diffusion of charged solute- driven by electrochemical gradient Z = charge on solute molecule F = Faradays constant (charge on 1 mole e-= 96480 coulombs/mol = Joules/voltmol) = electrical potential difference across membrane (volts) G = RT ln [ C 2 ] [ C 1 ] + ZF Simple diffusion of charged solute: chemical gradient + electrical gradient = electrochemical gradient 11-27 Active Passive = facilitated diffusion (Permease) Glucose transporter 11-29 11-30 v = V max [ S ] out [ S ] out + K t K t = K transport...
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CH11.Pt1 - to lipid tail Transport across membranes 11-25 4...

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