ch08 - 2. base composition of given species does not change...

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1 Nucleotides and Nucleic Acids Chapter 8 8-1 8-2 8-4 8-3b 9 1 8-4 N-glycosidic bond
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2 8-5 8-7 Nucleic acid polymers Base hydrolysis of RNA 8-10 Tautomeric conversions of bases 8-9 8-11
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3 DNA structure 2003 = 50 th anniversary of discovery of structure of DNA by Watson and Crick. Avery-MacLeod-McCarty experiments with pneumococcus (1944) and Hershey-Chase experiments with bacteriophage (1952) convinced most scientists that DNA was the genetic material. Chargaff and coworkers in late 1940’s analyzed DNA composition from many organisms and tissues and concluded these rules: 1. base composition varies from species to species, but is the same in different tissues of same species
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Unformatted text preview: 2. base composition of given species does not change with age, nutritional state, etc. 3. In all DNAs from any source: A=T and G=C 8-13 8-15 8-17 4 = inverted repeat 8-18 8-19a inverted repeat stem loop 8-19b 8-20 8-23 RNA Structure 8-24 RNA component of RNase P 5 Transfer RNA (tRNA) 8-25 8-26 8-27 8-28 Partially denatured DNA 8-29 Nonenzymatic transformation of DNA bases 8-30a 6 8-30b 8-31a 8-32 8-33a 8-33b 8-34 7 8-38 8-39 N N N N NH 2 O OH OH O P O O O P O O O P O O O N N S NH 2 N Adenosine thiamine triphosphate thiamine triphosphate adenosine Nature Chemical Biology 3, 211-212, 2007...
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ch08 - 2. base composition of given species does not change...

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