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ch04 - Protein Structure Chapter 4 3-23 3-13 4-2a 4-2(phi...

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1 Protein Structure Chapter 4 3-23 3-13 4-2a 4-2 φ (phi) = ψ (psi) = 0° 4-3 Ramachandran plot for L-Ala residues Secondary Structures α -helix β -sheet
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2 4-4 p = n•d 5-6 Å α -helix p n d =1.5 Å 4-4 α -helix Box 4-1 4-5 4-6a β -sheet
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3 4-7b β -sheet 7 Å ~4 Å 4-7a 4-7b Proline isomers Primary structure (aa sequence) determines secondary structure! -Leu-Lys-Gly-Glu-Leu-Lys-Gly-Glu-Leu-Lys-Gly-Glu- LYS GLU -Leu-Lys-Gly-Glu-Leu-Lys-Gly-Glu-Leu-Lys-Gly-Glu-
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4 LYS GLU + + + + - - - - - - - - - + + + + + + + 3-16 Tertiary Structures Tertiary Structures Fibrous Proteins - 2 types: 1. Globular subunits helically arranged into fibers (actin, tubulin) 2. extended or α -helical chains twisted together or bundled into fibers 4-10a 4-10b Box 4-2 Adjacent chains in the keratin filaments are crosslinked by disulfide bonds:
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5 4-13 Silk fibroin = aligned and stacked antiparallel β -sheets Collagen = right-handed triple helical cable (individual chains are left- handed) 4-11 -Gly-X-Y- 4-12 Prolyl hydroxylase (ascorbic acid = vit C) Deficiency --> scurvy (Box 4-3) fibrils
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