ch01 - Introduction Chapter 1 and pp. 495-501 Key Points:...

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1 Introduction Chapter 1 and pp. 495-501 Key Points: 1. Universality of biochemistry 2. Cells and compartments 3. Chemical reactivity 1-36 1-7a Electron micrograph of liver cell Molecular conformation is everything in biology! Configuration = fixed spatial arrangement of atoms in molecule conferred by double bonds, or by a chiral center . Configurational isomers cannot be interconverted without breaking a covalent bond
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2 1-19a 1-19b p. 17 RS system priorities: -SH > -OCH 2 > -OH > -NH 2 > -COOH > -CHO > -CH 2 OH > -CH 3 > -H enantiomers What is the configuration at the chiral center in this molecule? 3 1 2 7-2 1-21 Conformation
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3 1-23a ( S ) H3C S O - O NH3 + H O H3C S O - O O +H3N H Methionine S-oxide (sulfoxide) Nexium Prilosec ( R,S ) ( S ) 1-23b Chemical reactivity: there are no “metaphysics” in biochemistry – chemistry of living systems follows same chemical and physical laws as rest of nature. Complexity of biochemical systems may at first glance seem
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ch01 - Introduction Chapter 1 and pp. 495-501 Key Points:...

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