Additional slides for lecture 11

Genetics: A Conceptual Approach

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Last Time: Chromosomal Rearrangements 1) Duplication 2) Deletion Structure - tandem - displaced - reverse Effect on Meiosis Chromosome with duplication must loop when paired with a normal chromosome during prophase I Normal chromosome must loop when paired with a deleted chromosome during prophase I Effect on Phenotype Produces imbalance of gene products Often harmful- inappropriate levels of gene products can disrupt normal
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Unformatted text preview: development Generally, the larger the duplication or deletion, the more adverse the impact on phenotype Phenotypic Effects of Inversions Normal chromosome Chromosome with inversion gene broken into 2 parts- disrupts gene expression Normal chromosome Chromosome with inversion gene broken into 2 parts- disrupts gene expression position effect- may alter gene expression Phenotypic Effects of Inversions...
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This note was uploaded on 05/06/2010 for the course BIO 311 taught by Professor Otto during the Spring '10 term at George Mason.

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Additional slides for lecture 11 - development Generally...

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