Additional slides from lecture 23

Genetics: A Conceptual Approach

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Unformatted text preview: Last time Mutation = an inherited change in genetic information somatic mutation daughter cells germline mutation organisms in next generation Last time Different types of mutations : Categorized based on DNA change Base substitutions transition (R -> R or Y -> Y) transversion (R -> Y or Y -> R) Insertion (plus > 1 bp) Deletion (minus > 1 bp) Expanding trinucleotide repeats (increasing # of copies of repeat) Last time Different types of mutations : Categorized based on effect Missense mutation (change of 1 aa) Nonsense mutation (changes sense codon to stop; premature termination) Silent mutation (changes sense codon to synonymous codon; no aa change) Frameshift mutation (alters reading frameoccurs when insertion or deletion is not a multiple of 3 bps) Loss-of-function mutation Gain-of-function mutation Lethal mutation Conditional mutation Suppressor mutation ( intra genic or inter genic) Homework 18-17 a.If a single transition occurs in a codon that specifies Phe, what amino acids can be specified by the mutated sequence? Homework 18-17 a.If a single transition occurs in a codon that specifies Phe, what amino acids can be specified by the mutated sequence? Homework 18-17 a.If a single transition occurs in a codon that specifies Phe, what amino acids can be specified by the mutated sequence? Phe codons UUU or UUC Homework 18-17 a.If a single transition occurs in a codon that specifies Phe, what amino acids can be specified by the mutated sequence? Phe codons UUU or UUC DNA TTT TTC Homework 18-17 a.If a single transition occurs in a codon that specifies Phe, what amino acids can be specified by the mutated sequence?...
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This note was uploaded on 05/06/2010 for the course BIO 311 taught by Professor Otto during the Spring '10 term at George Mason.

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Additional slides from lecture 23 - Last time Mutation = an...

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