Additional slides from lecture 24

Genetics: A Conceptual Approach

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Last Time Mutagenic properties of radiation: Type of Radiation Causes ionizing radiation high energy double-standed (X-rays, gamma rays) DNA breaks UV radiation lower energy pyrimidine dimers
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repair system # nucleotides removed nucleotides removed by sealed by mismatch direct base excision nucleotide excision 0 N/A N/A (repair enzymes change mutant
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Unformatted text preview: base back to wild-type without removing any nucleotides) 1 glycosylase (removes base) AP endonuclease (removes sugar) many many DNA pol & ligase mismatch repair complex (3 -> 5 exonuclease activity) enzyme complex cleaves on both sides of damaged base Summary...
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Additional slides from lecture 24 - base back to wild-type...

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