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Topics for Final0

Genetics: A Conceptual Approach

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Topics for Final Exam Topics from chapters covered in Exams I and II New topics after Exam II: Chapter 13 - Different classes of RNAs - RNA polymerases and the RNAs they transcribe - Structures of bacterial and eukaryotic RNA Pol II transcription units - Process of transcription in bacteria and in eukaryotic cells, including details of initiation, elongation, and termination Chapter 14 - Colinearity of bacterial genes & noncolinearity of many eukaryotic genes - Major types of introns - Structures of bacterial mRNAs and eukaryotic pre-mRNAs - Pre-mRNA processing - tRNA and ribosome structures - RNA interference Chapter 15 - Definition of gene - Structure and functions of proteins (don’t have to know chemical structures of amino acids) - Experiments that deciphered the genetic code - Characteristics of the genetic code - Process of translation in bacteria, including details of tRNA charging, initiation, elongation,
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Unformatted text preview: and termination- Key differences between bacterial and eukaryotic translation Chapter 17- Different levels/mechanisms of control of gene expression in eukaryotes- Histone modification, chromatin remodeling, DNA methylation - Transcriptional activator proteins- Regulation of RNA splicing- Factors that affect RNA stability- Mechanisms of gene regulation by RNA interference Chapter 18- Types of mutations, including those characterized by molecular structure and phenotypic effects- Difference between spontaneous and induced mutations- Spontaneous replication errors & chemical changes- Chemically induced mutations- Types of mutations induced by different forms of radiation- DNA repair pathways Chapter 23- Oncogenes, proto-oncogenes, and tumor suppressor genes- Other genetic causes of cancer discussed in lecture...
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