Unformatted text preview: Lipid Metabolism Problem Set Reading: Chapter 22 (all) Chapter 26 Sections 26.2, 26.3, and 26.4 Problems: 1, 6, 8, 9, 11, 17 (a and b) and 19 Problems Chapter 22: 6, 8, 11, and 19 (really good review for the final) Chapter 26: 7, 10 plus problem set (Note: Reading and problems have been combined for oxidation and synthesis) 1. What two properties make triacylglycerols more efficient metabolic energy storage molecules than glycogen? 2. When energy charge and the concentration of oxaloacetate in the liver are both low, was is the fate of excess mitochondrial acetyl CoA? What metabolic conditions will bring this about? 3. Canitine acyltransferase deficiency is characterized by hypoglycemia and a lack of ketone bodies in the plasma during starvation. Use your knowledge of lipid metabolism to explain this condition. 4. Suppose you treat cultured adipocytes with an inhibitor to camp phosphodiesterase. How would this affect the adipocytes response to epinephrine? 5. Acetyl CoA Carboxylase exists in an inactive non-filamentous (protomer) form and an active filamentous form. Citrate binds preferentially to the filamentous form, while palmitolyl-CoA binds preferentially to the protomer (nonfilamentous) form. Explain how this observation is consistent with the role of acetyl-CoA carboxylase in fatty acid synthesis. 6. De novo cholesterol synthesis is drastically reduced when a diet high in cholesterol is consumed. Use your knowledge of cholesterol biosynthesis to explain this observation. 7. Explain the chemical characteristics that make bile salts effective biological detergents. ...
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- Spring '07
- Biochemistry, good review, metabolic energy, acetyl-CoA carboxylase, filamentous form