membrane transport practice problems

membrane transport practice problems - into the cell What...

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Membrane Transport Practice Problems First try these problems from Chapter 13 of your book (Berg et al., Biochemistry 6 th edition ), pages 379 – 380. Problems: 2, 3, 5, 6, 8, 14 (parts a and b only), and 20 (Note: You can find the structure of tetradoxin on page 364) Then try these: 1. For this problem, assume the cell has a membrane potential of -60 mV with the interior negative with respect to the exterior, and is being kept at a constant temperature of 25 °C. a) The concentration of glucose outside of a given cell is 5mM and inside the cell is 150 mM. Calculate the free energy change for the transport of glucose into the cell at 25 °C? What type of transport protein could be mediating the movement of glucose into the cell under these conditions? Explain your answer. b) The concentration of Na + ions outside a given cell is 5 mM and inside the cell is 150 mM. Calculate the free energy change for transport of Na
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Unformatted text preview: + into the cell. What type of transport protein could be mediating the movement of Na+ into the cell under these conditions? Explain your answer. 2. The resting K + channel is 100 times more permeable to K + than to Na + . Explain the molecular mechanism behind this specificity. 3. At pH 7, tryptophan crosses the membrane at a rate of about 1/1000 the rate of the closely related molecule indole. Explain this observation and comment on why pH is relevant to this question. 4. Under normal physiological conditions, the acetylcholine receptor gated ion channel transports Na+ more readily than K+. However, the channel itself is equally permeable to both Na+ and K+. Given that information, explain why upon binding acetylcholine, the vast majority of the ions flowing through the channel Na+ ions and NOT K+ ions....
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