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Unformatted text preview: 5. The disease beriberi results from a lack of thiamin in the diet. What two metabolites would you expect to accumulate in individuals with beriberi after ingesting glucose. 6. Explain why it makes sense that citrate inhibits the key glycolytic enzyme phosphofructokinase I. 7. When I was taking biochemistry as an undergraduate, succinyl-CoA synthase, which catalyzes the conversion of succinyl-CoA to succinate in a reaction that yields 1 molecule of GTP, was called succinate thiokinase. Why can this enzyme be classified as a kinase? 8. Explain why plants must have an active glyoxylate pathway but this pathway is not necessary (and in fact not present) in animals. 9. Why have some proposed to develop inhibitors of enzymes in the glyoxylate pathway as antimicrobial agents? What type pathogens might be susceptible to this type of inhibitor?...
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- Spring '07
- Biochemistry, Oxaloacetate, pyruvate dehydrogenase, citrate cycle, 29.7 kJ