Unformatted text preview: 2. What aspect of the insulin response would be affected by permanently inactivating ras GTPase activity? Why? If ras cannot hydrolyze GTP it will be constitutively active, leaving the gene expression aspects of the insulin response permanently turned on. 3. Non-hydrolyzable analogs of GTP (see example below), are often used to study G proteins in the laboratory. How would one of these analogs affect epinephrine signaling? cAMP production by adenylate cyclase? A non-hydrolyzable analog of GTP would leave the G α s in the “on” state. As a result, adenylate cyclase would continue to make cAMP and the epinephrine response would be prolonged....
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- Spring '07
- Biochemistry, amino acid substitutions