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Unformatted text preview: 2. What aspect of the insulin response would be affected by permanently inactivating ras GTPase activity? Why? If ras cannot hydrolyze GTP it will be constitutively active, leaving the gene expression aspects of the insulin response permanently turned on. 3. Non-hydrolyzable analogs of GTP (see example below), are often used to study G proteins in the laboratory. How would one of these analogs affect epinephrine signaling? cAMP production by adenylate cyclase? A non-hydrolyzable analog of GTP would leave the G s in the on state. As a result, adenylate cyclase would continue to make cAMP and the epinephrine response would be prolonged....
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This note was uploaded on 05/06/2010 for the course BIOC 460 taught by Professor Ziegler during the Spring '07 term at University of Arizona- Tucson.
- Spring '07