signal transduction practice problems

signal transduction practice problems - 2 What aspect of...

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Signal Transduction Practice Problems First try these problems from Chapter 14 of your book (Berg et al., Biochemistry 6 th edition ), pages 405-407, Problems 1, 2, 4, 5, 6, 9, and 10 Then try these: 1. Explain how amino acid substitutions in the R or C subunit of cAMP-dependent protein kinase (PKA) could lead to a PKA enzyme that is always active? How could amino acid substitutions lead to a PKA enzyme that cannot be activated?
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Unformatted text preview: 2. What aspect of the insulin response would be affected by permanently inactivating ras GTPase activity? Why? 3. Non-hydrolyzable analogs of GTP such as GTP γ S (see structure below) are often used to study G proteins in the laboratory. How would one of these analogs affect epinephrine signaling? cAMP production by adenylate cyclase?...
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