Unformatted text preview: Final Exam Study Guide We consider the final very conceptual. In many questions you will be asked to apply the concepts you learned in the class to new situations. In some cases you will be given the choice of which question to answer. In order to do this, we have cut a number of topics from the final. What will NOT be on the final: Hemoglobin Chymotrypsin, HIV protease (but that does not mean no enzyme mechanisms) Protein folding Enzyme inhibition Protein Methods Membrane fluidity Direct questions on fatty acid or carbohydrate structures Names of proteins in the signal transduction pathways (but you do need to know how signaling pathways work) Photosynthesis/Calvin Cycle Calculating ATP yields What equations you need to have memorized: None! Dr. Tama and I both agree you have proven yourselves adept at calculating free energy changes. NO CALCULATORS ARE NECESSARY What you still need to know/understand: Chemical properties of the amino acids Protein structure, all levels, effect of mutations on structure How to interpret graphs shown in both sections of the course Common type of catalysis How to interpret effect of mutations based on kinetics data kcat (Vmax), kM How structural features relate to the function of membrane transport proteins and multisubunit complexes that catalyze metabolic reactions (e.g. ATP synthase) Facilitated diffusion versus active transport Biochemical basis of the early steps in insulin and glucagon signaling (i.e. receptor binding to activation of IRS-1/heterotrimeric G protein) Substrates/products/regulated enzymes for the major metabolic pathways How and why metabolic pathways are compartmentalized in the cell Interplay between metabolic pathways How metabolic pathways are regulated (allostery, hormonal regulation, compartmentalization, and AMP-kinase) Don't forget- this exam will focus on concepts! If you are able to the biochemical basis of some of the diseases, drugs, toxins, diets, and interesting animals discussed in class, then you likely have a good understanding of the major concepts in metabolism. . ...
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This note was uploaded on 05/06/2010 for the course BIOC 460 taught by Professor Ziegler during the Spring '07 term at Arizona.
- Spring '07