metabolic integration

Obesity is also a risk factor for a number of cancers

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: and Brown Remember, brown adipose 4ssue Is not just for bears! White adipose 4ssue differs based on distribu4on throughout the body Visceral fat- abdominal fat surrounding organs Subcutaneous fat- beneath the skin Adipocytes: Not just for storing fat.... From Rosen and Spiegelman Nature 444, 847-853(14 December 2006) Proteins secreted by adipocytes Diabetes linked to inflammation Adipocyte circulating FFA, ectopic fat deposition Increased Inflammation NEFA TNF- IL-6 Resistin Adiponectin Anti-inflammatory compounds that reduce insulin resistance Pro-inflammatory compounds that cause insulin resistance Adapted from Teresa White/Tsu-Shuen Tsao Not all fat is the same: Adipocytes from different regions of the body have different metabolic profiles Visceral fat - secretes faqy acids into the portal vein->liver - secretes inflammatory molecules Subcutaneous fat is more responsive to insulin Visceral fat associated with higher rates of heart disease and higher rates of diabetes- explain this with what we learned about adipocyte biology. Lep4n, an adipocyte-secreted factor, regulates appe4te and metabolism Lep-n Controls Appe-te and Energy Expenditure Unfortunately, this did NOT work in humans. Why? Adapted from Dr. R.L. Miesfeld...
View Full Document

This note was uploaded on 05/06/2010 for the course BIOC 460 taught by Professor Ziegler during the Spring '07 term at Arizona.

Ask a homework question - tutors are online