metabolic integration

metabolic integration - Lecture 38 Metabolic Integra4on...

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Lecture’38:’Metabolic’Integra4on,’Diabetes,’and’Obesity’ Bioc’±60’Spring’2010’Dr.’Lisa’Rezende’ How’are’metabolic’ pathways’regulated’in’ humans?’ Why’do’pa4ents’with’ diabetes’have’difficulty’ controlling’blood’sugar’ and’what’can’be’done’ to’treat’it?’ What’role’do’ adipocytes’play’in’ diabetes’and’obesity?’
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Learning Objec-ves Describe’the’metabolic’needs’and’func4ons’of’the’liver,’pancreas,’ brain,’adipose’4ssue,’and’skeletal’muscle.’ Review’the’pathways’ac4ve’in’the’organs’listed’above.’ Describe’the’molecular’events’leading’to’insulin’secre4on’in’response’ to’increasing’blood’glucose,’including’the’biochemical’features’of’ Review’the’metabolic’eFects’of’glucagon’and’insulin.’ Describe’the’two’major’forms’of’diabetes,’explain’why’“non-insulin’ dependent’diabetes’is’a’misnomer,’and’discuss’treatment.’ Explain’why’“prediabetes”’is’now’commonly’diagnosed’and’treated.’ Outline’the’path’from’obesity’to’type’2’diabetes.’ Discuss’the’role’of’adipose’4ssue’as’a’secretory’organ’and’its’impact’ on’both’type’2’diabetes,’appe4te’control,’and’energy’use.’ Reading: Chapter 27 (not all covered here but good review for Fnal) Problems: 1,’2’(a,b,c,d,and’f),’8,’and’10
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Each’organ’has’its’own’metabolic’needs’and’func4ons’
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A liver-centric view of human metabolism What are the two metabolic fuels exported by the liver? Courtesy’of’Dr.’R.L.’Miesfeld’
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Blood glucose must be -ghtly controlled Electron’micrograph’of’ Insulin’secre4on’
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Pancrea-c β cells act as glucose sensors Features: 1.’Glucokinase’has’a’higher’ Km’than’other’isoforms’ of’hexokinase’ 2.’Increasing’concentra4on’of’ ATP’closes’an’ATP-gated’ Ion’channel’ 3.’Membrane’depolarizes’in’ Response’to’channel’closing’ ±.’Voltage’gated’calcium’ channel’opens’in’response’ To’membrane’depolariza4on.’
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metabolic integration - Lecture 38 Metabolic Integra4on...

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