#4 NST 160 2010 Fit Fat Beta Cell Metab Sd

#4 NST 160 2010 Fit - NST 160 Complicating Factors Body Fat Distribution Fitness/Fatness Question-Cell Failure and DM2 and Metabolic Syndrome Marc

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  NST 160 Complicating Factors: Body Fat Distribution, Fitness/Fatness Question, β -Cell Failure and DM2, and Metabolic Syndrome Marc K. Hellerstein, M.D., Ph.D. Professor of Human Nutrition (D.H. Calloway Chair), University of California Berkeley; Professor of Endocrinology, Metabolism and Nutrition, Dept. of Medicine, University of California at San Francisco
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  Is all fat the same? Is there good fat and bad fat? 1) Fat location: central vs gluteo-femoral adipose, or subcutaneous vs internal (“apple” vs “pear” shaped obesity) - Central obesity, or internal fat, is associated with much worse health outcomes 2) Cell size and number (“hypertrophic” vs “hyperplastic” obesity): big fat cells are worse to have than many small fat cells 1) Is All Body Fat the Same?
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  Why might type of fat stores matter? 1) tendance to release fats into the bloodstream: big fat cells and visceral fat cells release more fatty acids (are more lipolytic) 2) Adequacy of adipose fat storage capacity : paradoxical effects of lipoatrophy, drug therapies that increase subcutaneous fat 2) Consequences of fat in tissues (non-adipose): “metastatic fat syndrome” 3) So, the fat in adipose stores (under the skin) may not be the real problem – it is when it spills into the rest of the body that trouble occurs Is All Body Fat the Same?
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  - What is “fitness”? Capacity to do aerobic work - Can one person be “fat” and “fit”? How? Examples (e.g., Sumo wrestlers) - How many people are “fat” and “fit”? Thin but “unfit”? -
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This document was uploaded on 05/07/2010.

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#4 NST 160 2010 Fit - NST 160 Complicating Factors Body Fat Distribution Fitness/Fatness Question-Cell Failure and DM2 and Metabolic Syndrome Marc

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