#5 NST 160 CR - Calorie Restriction & Aging NST 160 Matt...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
  NST 160 Matt Bruss Graduate Student Hellerstein Lab Calorie Restriction & Aging
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
“Undernutrition without malnutrition” Reduced kcals, adequate nutrients Caloric restriction (CR) extends mean & maximal lifespan. - In nearly every species tested rats, mice, fish, flies, worms, yeast and most recently non-human primates. Major health effects of CR Reduced carcinogenesis; reduced renal disease Increased insulin sensitivity; leaner and smaller Improved cardiovascular health; greater activity Enhanced immune system;prolonged reproduction
Background image of page 2
History of Calorie Restriction Clive McCay 1935 first to describe CR leads to increased lifespan in rats
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
CR: Increased Mean & Maximal lifespan
Background image of page 4
CR: Increased “Health Span” CR seems to delay aging not just prolong lifespan Delays the onset of nearly every age related disease. age-associated increase in age-specific mortality is dramatically decelerated in CR rats ( Gompertzian analysis) Extrapolating decline in aging to humans would allow 90 year olds to have the physical attributes of 50 year olds.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Why study mechanisms of CR effects? Learn about fundamental mechanisms of aging. Develop lifestyles and/or therapeutics to delay aging.
Background image of page 6
CR: Mechanisms Decreased EE (Rate of living theory) Decreased food intake Decreased body weight Decreased Fat mass Decreased Oxidative stress/free radicals Change in fuel metabolism Hormesis Stem cell maintenance/decreased cell proliferation
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

This document was uploaded on 05/07/2010.

Page1 / 11

#5 NST 160 CR - Calorie Restriction & Aging NST 160 Matt...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online