Lecture 13 cardiovascular 1

Lecture 13 cardiovascular 1 - 1 Office Hours Lehman: TTh...

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Unformatted text preview: 1 Office Hours Lehman: TTh 10-11 am 5112 VLSB slehman Kaufer: M 12-1, F 9-10, F 10-11 5155A VLSB danielak Gross: W, Th 3-4 pm 5112 VLSB sgross 2 Today: Ch 12 A,B Cardiovascular Physiology 1. Overview A. Blood B. Cardiovascular system 2. The heart A. Anatomy B. Heartbeat coordination C. Mechanical events of cardiac cycle D. Cardiac output 3 1. Overview of the Circulatory System • Functions of circulation • Components: – Blood – Heart – Blood vessels Cardio- vascular System 4 Functions of Circulation • Supply O 2 and Nutrients • Remove ‘Wastes” • Temperature Regulation • Distribute hormones • Immuno-vigilance 5 Blood • Plasma ~55% of 5.5L = 3.0L • Cells and cell fragments ~45% of 5.5L – Erythrocytes > 99% – Leukocytes, platelets • Hematocrit: volume of erythrocytes/total blood volume; ~0.45 = 45% 6 Plasma includes water, ions, proteins, nutrients, hormones, wastes, etc. The hematocrit is a rapid assessment of blood composition. It is the percent of the blood volume that is composed of RBCs (red blood cells). igure 12-1 7 William Harvey (1578-1657) 1628: De Motu Cordis An Anatomical Study of the Motion of the Heart and of the Blood in Animals The heart beats ~ 72 times per min About 70 ml flows out per beat 70 ml x 72 per min = 5000 ml per min ~5 L/min x 60 min/hr = 300 L/hr Harvey estimated: Harvey concluded: that much blood can’t be generated by the liver! arvey observed: arvey concluded: he blood circulates eating hearts in living animals inch venous input: eart empties inch arterial utput: heart swells entricles push blood ut through arteries tria collect venous lood from lungs and ystemic circ. The Blood Circulates! 8 http://www.nlm.nih.gov/hmd/medieval/arabic.html Not to be too Eurocentric … Ali ibn al-'Abbas al-Majusi, fl. 940-980 (known as Haly Abas). Kamil al-sina'ah al-tibbiyah . Ibn Nafis (1210 -1288 ) hypothesized existence of pulmonary and systemic circulations ~400 years before Harvey. 9 The Circulatory System: 4 Heart Chambers, 2 Circuits RA RV LA LV Systemic Pulmonary 10 Two circuits: Systemic and Pulmonary Systemic • Left Ventricle sends blood to all organs and tissues except lungs • Right Atrium receives venous blood • Right AV valve lets blood flow to Right Ventricle (when A pressure > V pressure) Pulmonary • Right Ventricle sends blood to lungs • Left Atrium receives oxygenated venous blood • Left AV valve lets blood flow to Left Ventricle (when A pressure > V pressure) 11 The heart is the pump...
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This note was uploaded on 05/07/2010 for the course INTEG BIO 132 taught by Professor Lehman during the Spring '10 term at Berkeley.

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Lecture 13 cardiovascular 1 - 1 Office Hours Lehman: TTh...

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