Lecture 17 Renal_Principles

Lecture 17 Renal_Principles - Lecture 16: Renal System --...

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Unformatted text preview: Lecture 16: Renal System -- Principles Office Hours Lehman: TTh 10-11 am 5112 VLSB slehman Kaufer: M 12-1, F 9-10, F 10-11 5155A VLSB danielak Gross: W, Th 3-4 pm 5112 VLSB sgross 2 Midterms Midterm 1: Grading rubric is on pp 2-3 of syllabus Key is posted in the glass-covered bulletin board nearest my office Scantrons available in 3018 VLSB Tu&W 10-12 Midterm 2: March 30 in class; same format as midterm 1; bring RED scantrons, pencils Covers all material since midterm 1 3 Readings This Week For Today: Chapter 14, Section A For Next Lecture (Renal Control): Chapter 14 B,C,D 4 Todays Outline: Renal Principles 1. Renal functions 2. Structure of Kidneys and Urinary System 3. Basic principles of renal physiology 5 Kidney Functions 1. The principal function of the kidney is to maintain homeostasis of Extracellular Fluid fluid volume ion concentrations acid-base balance 2. Kidneys also excrete metabolic wastes and many non-biological chemicals, and synthesize glucose during prolonged fasting 6 Claude Bernard (1813-1878) invented the homeostasis concept The primary function of the kidneys is to maintain homeostasis of the extracellular fluid (ECF) 7 Mode of operation: filter the blood, then reabsorb almost everything The kidneys filter about 125 ml/min 180 L/day About 11 L during this class They reabsorb over 90% of the plasma that they filter 99% of water 99.5% of Na 100% of glucose 8 9 The paired kidneys form a filtrate of the blood that is modified by reabsorption and secretion; urine moves along the ureters to the bladder and out through the urethra. Figure 14-1 The Urinary System 10 Figure 14-4 Kidney Structure The outer layer of the kidney is the renal cortex ; it is the site of glomerular filtration as well as the convoluted tubules. Renal cortex The inner part of the kidney is the renal medulla ; this is the location of the longer loops of Henle, and the drainage of the collecting ducts into the renal pelvis and ureter. Renal medulla 11 igure 14-4 Each kidney has ~1 million functional units, called nephrons 12 A NEPHRON consists of: Renal Corpuscle Renal Tubule Fig. 14-2a The functional unit of a kidney is the Nephron The Renal Corpuscle is in the cortex; the renal tubule begins at the corpuscle, and descends into the edulla 13 Figure 14-3 The Renal Corpuscle is the apparatus for filtration lood enters the renal corpuscle ia the A fferent Arteriole A Glomerulus: ~50 looped capillaries where blood pressure filters fluid into Bowmans capsule 80% of the blood that entered exits the renal corpuscle via the E fferent Arteriole Fenestrae in the capillaries and filtration slits between podocytes allow filtration. 14...
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Lecture 17 Renal_Principles - Lecture 16: Renal System --...

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