Lecture 18 Renal_Control

Lecture 18 Renal_Control - Lecture 17: Renal Control Office...

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Unformatted text preview: Lecture 17: Renal Control Office Hours Lehman: TTh 10-11 am 5112 VLSB slehman Kaufer: M 12-1, F 9-10, F 10-11 5155A VLSB danielak Gross: W, Th 3-4 pm 5112 VLSB sgross 2 Todays Outline: Renal Control 1. Regulation of water balance 2. Regulation of Na + 3. Regulation of K + 4. Regulation of acid/base balance 3 Readings For Today: Chapter 14 B,C,D For next week (Spring Break suggestions): Jose Saramago, Baltazar and Blimunda Marcel Proust, Swanns Way Elizabeth Gilbert, Eat, Pray, Love 4 Fluid Balance Extracellular fluid serves as the intermediary between cells and the extracellular environment. Plasma is the only fluid that can be acted on directly to control its volume and composition. Because of free exchange across capillary walls, ECF volume and composition are regulated when plasma volume and composition are. 5 Control of Fluid Balance Two factors are regulated to maintain fluid balance: ECF osmolarity Important to prevent swelling or shrinking of cells Control of water balance is of primary importance ECF volume Important to maintain blood pressure Control of salt balance is of primary importance 6 Control of Water Balance is of primary importance in regulating ECF osmolarity Daily water input and output are well balanced. Two factors can be controlled: Thirst influences the amount of fluid ingested The kidneys can adjust how much water is excreted as urine Water reabsorption is controlled (and can be regulated) in the medullary collecting ducts 7 The kidneys balance water loss with water gain 8 Hypothalamic Osmoreceptors Increased osmolarity (too little H 2 O) is sensed by osmoreceptors in the hypothalamus These osmoreceptors signal thirst and cause release of vasopressin. Vasopressin causes increased permeability of the collecting tubules, leading to more H 2 O reabsorption. 9 Hypothalamic Osmoreceptors 10 Vasopressin is the signal for regulating ECF osmolarity Vasopressin is released by the posterior pituitary in response to increased osmolarity Fig 14-25 Vasopressin is also known as Antidiuretic Hormone (ADH). Diuretic Means increased urine output. 11 Because ECF osmolarity affects blood pressure, vasopressin is also released by...
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Lecture 18 Renal_Control - Lecture 17: Renal Control Office...

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