lipoproteinsFeb28,2010 - Cells can make cholesterol or...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Cholesterol is a major lipid component of cell membranes. Cholesterol serves to: 1. Immobilize acyl chain of membrane phospholipids 2. Decreases permeability to small water-soluble molecules. 3. Prevents crystallization of hydrocarbons and phase shifts in the membrane. Cells can make cholesterol or obtain it from the diet.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cholesterol is a precursor of steroid hormones Minor pathway in terms of the amount of cholesterol required yet important physiologically Cholesterol Aldosterone
Background image of page 2
Bile Acids - Intestinal Detergents Bile acids (e.g. deoxycholic acid) are produced from cholesterol in the liver and secreted into the intestine via the gall bladder. Bile acids are oxidation products of cholesterol. The main function of bile acids is to act as a soap or detergent in the digestive processes. Bile acids emulsify fats and oils into smaller droplets facilitating enzymatic break down of the dietary fat. Deoxycholic acid Cholesterol
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
lipase bile acid triglyceride Bile acids are good detergents because their polar moieties reside on one face of their planar structure
Background image of page 4
The liver produces bile acids from cholesterol and it is stored in the gall bladder. After a fatty meal, bile is secreted into the small intestine. Digestion and assimilation of lipids liver stomach pancreas gall bladder intestine Bile acids from gall bladder Lipid degrading enzymes from pancreas Fat droplet
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Bile acid recirculation affects blood cholesterol levels Excretion of bile in the feces is the major way our body eliminates cholesterol. Increased excretion of bile results in increased demand for bile production in the liver, thereby reducing cholesterol content. Cholesterol Bile excretion
Background image of page 6
Ursodeoxycholic acid Bear bile is claimed to cure fevers and liver ailments, liven up a sagging love-life and promote general well- being. The bile-producing gall-bladder is so highly sought after that in Korea a single such organ can fetch as much as US $45,000.
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/07/2010 for the course NUTRI SCI 160 taught by Professor Hellerstein during the Spring '10 term at University of California, Berkeley.

Page1 / 33

lipoproteinsFeb28,2010 - Cells can make cholesterol or...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online