PMI 126 - Lecture 1

PMI 126 - Lecture 1 - PMI 126 Lecture 1 =...

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PMI 126 - Lecture 1 = [email protected] (Dr. J.L. Stott) [email protected] (Dr. T Sitt) - assisting No final. Grading is based on 3 midterms 33% (1/26), 34% (2/18), 33% (3/11) - predominantly multiple choices - only covered materials in class - 2nd midterm is NOT comprehensive, 3rd midterm is 3-5% comprehensive (general ideas) - require UC Davis 2000 scantron form - no curve Textbook: Kuby Immunology 6th edition (read based on slides) --------------------------------------------------------------------------------------------------------------------------- Immune system divides into two types: - innate : what you are borne with, never change its quality and quantity, doesn't provide you specific immunity (doesn't alter the immune system by vaccine) - adapted (acquired): immunity that's required over the life. = starts with ground zero, less than that is immune infection immune response is specific = correctly immunalization. Virus strain different by one amino acid will induce
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either half response or non. Self antigens are eliminated in early development, if not = autoimmune disease Downside of immune system: - hypersensitivity (allergy): caused by acquired immune responses (not borne with it) - rejection to tissue transplant * proteins of foreign tissue causes: Immunogenicity; is the ability of a particular substance, such as an antigen or epitope , to provoke an immune response . * immunosuppressive drugs are used to inhibit activity of the immune system. => each time it's used, the immune system is damaged. You become much more susceptible to infection - Leukemia is a cancer of the blood or bone marrow and is characterized by an abnormal proliferation (production by multiplication) of blood cells , usually white blood cells (leukocytes). * large amount of produced cells every single day increases the chance of having mutation
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PMI 126 - Lecture 1 - PMI 126 Lecture 1 =...

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