PMI 126 - Lecture 7

PMI 126 - Lecture 7 - PMI 126 Lecture 7 Antibody-antigen...

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PMI 126 – Lecture 7 Antibody-antigen interactions occurs at the very end of the antibody (binding site of the antigen) antigen binding site is formed by variable region of heavy chain and light chain combining. The binding has extremely high affinity Antibody has the 2 hinge regions (more flexibility) 1) Between heavy and light chain pairing together 2) Between variable and constant light part + variable-constant heavy part Four major forces create the antibody-antigen interactions: 1. electrostatic forces 2. hydrogen bonds 3. Van der Waals forces 4. Hydrophobic forces Antibody specificity: - extremely specific - differing by one reactive group will generate different antibody with different binding - this also shows how big the repertoire of the antibody responses is. - <= Haptens Antibody Cross-Reactivity: - not every antibody has perfect specificity Ex. Cow pox virus protects against small pox virus There are enough immunogen on cow pox that resembles the small pox virus enough. The antibody against cow pox virus can cross react the small pox virus Ex. Streptococal cell wall antigens can induce antibody that can also bind cardiac tissue (rheumatic fever) Downside of cross-reactivity (shared epitope) Specific protein on the bacteria that resemble the protein on the heart. Once the antibody against this epitotpe, this antibody can also against the protein of the heart. Ex. Bacteria in the gut can induce production of antibodies against it that can cross-react with blood cell antigens. basis of ABO group system . CHART There are two different alleles in the population of the basic O protein, A and B. Adaptive immune system is tolerant to “self” protein. eye ball and sperm <= two areas that antibody will not see. * potentially foreign Five Major Classes (isotypes) of Antibody: - depends on the constant region of heavy chain. - B cells just came out from the bone marrow, always express IgM and IgD
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This note was uploaded on 05/09/2010 for the course PMI PMI 126 taught by Professor J.l.stott during the Winter '10 term at UC Davis.

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PMI 126 - Lecture 7 - PMI 126 Lecture 7 Antibody-antigen...

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