PMI 126 - Lecture 14

PMI 126 - Lecture 14 - PMI 126 Lecture 14 Th2 and Th1...

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PMI 126 – Lecture 14 Th2 and Th1 cannot be distinguished by the surface proteins but can be distinguished by the type of cytokine secreted . Secreted cytokine determines the class switch of B cell. When naive helper T cells encounter the dendritic cell which is presenting the MHC II: peptide, the immediate microenvironment when the interaction occurs can determine whether the naïve T cell is going to be Th1, Th2, Th17, or regulatory T cell. Activation, proliferation and differentiation of B lymphocytes CD40L deficiency > hyper IgM immunodeficiency “SMACK” => tight interaction between T helper cell and B cell. reorganization of cytoskeleton in T cell allows the T cell to secrete IL-4 directly to the surface of B cell (this minimizes the bi-standard effect under the influence of IL-4, B cell would proliferate and undergo both class switch and affinity maturation. (occur in lymph node) Cytokine of T helper cell secretes determine the class of Ig secreted by the plasma cells. End products are memory cell and plasma cell (both are long-lived) T helper cells are the coordinator of the immune system!!!! - All the naïve B cell and T cell migrate from the blood to the organized lymphoid tissue via HEV. - both naïve B and T cells interact with the dendritic cell that’s carrying the antigen. Humoral Immune responses Develop in organized lymphoid structures Ag-Driven B cell Proliferation (A two-phase process) paracortex: most the T cells are. Follicle: where the B cells go Phase 1 : Primary foci are formed by the Ag- activated B cells in the medullary cord. There are
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some proliferations of both B cell and T cell. Some B cell would immediately differentiate into plasma cell (secrete IgM) (about 5 days) Inflammation is due to the contraction of endothelial cells at the site of infection which causes the leakage of fluid and leaks out into the tissue. (swelling) IgM would be carried into the site of infection. Phase 2
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PMI 126 - Lecture 14 - PMI 126 Lecture 14 Th2 and Th1...

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