Lab Report Template

Lab Report Template - Insert TITLE here Insert NAME and...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Insert TITLE here Insert NAME and SECTION NUMBER here Insert ABSTRACT here Introduction Diabetes is on the rise as a serious health threat to young people, with diagnosis of symptoms formerly found mostly in adults becoming more frequent in teenagers and young children (Debelea et al. 2007; Hsia et al. 2009). Diabetes can lead to a number of health problems including impaired kidney function or ultimately kidney failure if not properly managed. Moderate kidney dysfunction can prevent normal regulation of the acid-base balance in the blood and result in a condition known as metabolic acidosis ( Kovacic 2003; Uribarri 2000). Over time, metabolic acidosis can in turn result in problems with mineral homeostasis and cause a loss of bone density (Alpern and Sakhaee 1997; Kraut 2000; Weger et al., 2000). In adults this causes osteoporosis, but in children and teenagers impaired bone development may cause growth retardation (Alpern and Sakhaee 1997; Kovacic 2003). Minerals stored in bone as hydroxyapatite are used to dynamically buffer changes in blood pH that exceed the capacity of respiratory CO 2 to modulate ( Arnett, 2008). Minerals are continuously added to bone by osteoblasts, and may be liberated by osteoclasts in response to acidic blood pH (Arnett, 2008). Previous studies have established a correlation between mutations or deficiencies in activity of the enzyme alkaline phosphatase (AP) and defects in bone mineralization in children, suggesting a key
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
role for AP in normal bone development (for example Henthorn et al, 1992). Given that AP is important for bone mineralization and has optimum activity under alkaline
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/09/2010 for the course BSCI 105 taught by Professor Jensen during the Spring '07 term at Maryland.

Page1 / 6

Lab Report Template - Insert TITLE here Insert NAME and...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online