19. TB - Outline Tuberculosis Some basics Diagnosis Therapy...

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1 Tuberculosis Michael Gardam Tuberculosis Clinic, Toronto Western Hospital Outline Some basics Diagnosis Therapy Latent infection Active Disease CDN STDs 2000 Annual risk is not constant Risk of developing active disease Years after exposure High Risk Period Risk factors for infection
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2 CDN STDs 2000 Risk factors for progression Condition Relative risk AIDS 170 Transplantation 20-74 Silicosis 30 Chronic renal failure 10-25 Head and neck cancer 16 Recent infection <2 yrs 15 Fibronodular disease 6-19 Diabetes mellitus 2-4 Underweight 2-3 Age of infection (<5 yrs) 2-5 Granuloma 2 Corticosteroid use Ò increasedÓ Canadian Standards, 2000 Infection versus Disease Latent Infection Active Disease Burden of organisms Low High Symptoms None None-florid Transmissibility Not infectious Usually infectious Mantoux Positive Often positive CXR Usually normal, Occasionally old disease Usually abnormal, Infiltrates, cavities Therapy Optional: Preventative therapy Required: 4 drugs pending sensitivities Diagnosis of active disease weight loss fevers chills night sweats chronic cough hemoptysis fatigue local symptoms swollen nodes headache dysuria pleurisy back ache/bone pain chronic enteritis
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3 Diagnosis of active disease Cultures the affected site Molecular testing e.g. AMTD Other tests may help Radiology Biochemistry
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This note was uploaded on 05/09/2010 for the course LMP 232 taught by Professor Crandall during the Spring '10 term at University of Toronto- Toronto.

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19. TB - Outline Tuberculosis Some basics Diagnosis Therapy...

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