4. Chicken Pox and Prions

4. Chicken Pox and Prions - Varicella Zoster Virus (VZV,...

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Chicken Pox, Prions and Tropical Fevers Varicella Zoster Virus (VZV, chickenpox) • highly contagious; >90% of cases occur in children <9 years of age • infectious 2 days before until full crusting • winter, spring; incubation period 10 - 21 days • airborne; direct contact with lesions • subclinical infections may occur - uncommon • immunity is lifelong but latent in nerve root ganglia reaction (shingles / zoster) Varicella Zoster Virus A) Chickenpox - fever, irritability, vesicles spread over 4 - 7 days • majority uncomplicated - more severe in adults, pregnant women • disseminated in immunocompromised patients 3 Clinical Syndromes: Varicella Zoster Virus B) Zoster (Shingles) - dermatomal distribution; • reactivation of latent virus • zoster infectious to others they get chickenpox, not zoster • scarring; post-herpetic neuralgia C) Congenital Varicella - uncommon; 2% of fetuses borne to mothers with chickenpox in 1st 20 wks • limb hypoplasia, CNS retardation, muscular
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This note was uploaded on 05/09/2010 for the course LMP 232 taught by Professor Crandall during the Spring '10 term at University of Toronto- Toronto.

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4. Chicken Pox and Prions - Varicella Zoster Virus (VZV,...

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