11. Herpes Virus - Herpesviridae Family double stranded DNA...

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Herpes Viruses Herpesviridae Family • double stranded DNA viruses with envelope • ubiquitous, world-wide distribution • 8 human herpes viruses recognized; species specific • Latency - “once infected, always infected” - site varies with virus type: HSV 1 & 2, VZV - sensory nerve ganglia; CMV, EBV, HHV6, HHV7 - lymphocytes Transmission & Seroepidemiology of Herpesviridae Mode of Transmission Seroprevalence (%) Perinatal Blood Intimate Aerosol Healthy Healthy Virus Products Contact Children Adults HSV 1 + - + - 20 - 40 50 - 70 HSV 2 + - + - 0 - 5 20 - 50 VZV + - + + 50 - 75 85 - 95 CMV + + + - 10 - 30 40 - 70 EBV + + + - 10 - 30 60 - 90 HHV6 ? ? ? ? 80 - 100 60 - 100 HHV7 ? ? ? ? 40 - 80 60 - 100 Herpesviridae • do not survive for prolonged periods in the environment • requires inoculation of fresh virus- containing body fluid of infected person into susceptible tissue of uninfected person • may be transmitted during primary or reactivation infections; often the person shedding virus is asymptomatic Transmission: Herpes Simplex Viruses Characteristic HSV-1 HSV-2 Urogenital infections 10 - 30% 70 - 80% Nongenital infections: Labialis 80 - 90 % 10 - 20 % Keratitis + - Whitlow (hand) + + Encephalitis (adult) + - Neonatal infection 30 % 70 % Transmission primarily non-genital primarily genital Herpes Simplex Virus • humans are the only natural reservoir; HSV-1: 70 - 80 %, HSV-2: 20 - 50% • spread via contact with infected secretions: • transmission both during lesions or
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11. Herpes Virus - Herpesviridae Family double stranded DNA...

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