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13. Diagnosis of Viral Infections

13. Diagnosis of Viral Infections - Diagnostic Virology Why...

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Diagnostic Virology Diagnostic Virology Why bother? It is important information for: A. Transplantation viral infections HIV severity of infections B. Effective chemotherapy (the choice of anti-viral may depend on the nature of the virus) C. Epidemiology (we need to know what’s out there) Diagnostic Virology Rapid Dx: tests / investigations allow discontinuation of antibiotics earlier effective treatment early detection and management of epidemics safe transplantation / transfusion Diagnostic Virology Three common methods: 1. Virus isolation 2. Direct detection 3. Serology 4. PCR is coming Diagnostic Virology 1. Virus Isolation: Common methods: • tissue culture • chick embryo • animal inoculation Specimen Collection for Viral Culture obtain material from infected organ(s) (not always possible or practical) sampling of multiple sites (eg. resp. tract and urine for measles virus) definitive diagnosis vs presumptive diagnosis (eg. measles virus vs enteroviruses)
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